Transforming growth factor beta induces sensory neuronal hyperexcitability, and contributes to pancreatic pain and hyperalgesia in rats with chronic pancreatitis

Transforming growth factor beta induces sensory neuronal hyperexcitability, and contributes to pancreatic pain and hyperalgesia in rats with chronic pancreatitis

<p>Abstract</p> <p>Background</p> <p>Transforming growth factor beta (TGFβ) is upregulated in chronic inflammation, where it plays a key role in wound healing and promoting fibrosis. However, little is known about the peripheral effects of TGFβ on nociception.</p>...

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Bibliographic Details
Main Authors: Zhu Yaohui, Colak Tugba, Shenoy Mohan, Liu Liansheng, Mehta Kshama, Pai Reetesh, Zou Bende, Xie Xinmin, Pasricha Pankaj J
Format: Article
Language:English
Published: SAGE Publishing 2012-09-01
Series:Molecular Pain
Subjects:
Transforming growth factor beta
Chronic pain
Neuronal sensitization
Kv channels
Sensory neurons
Chronic pancreatitis
Online Access:http://www.molecularpain.com/content/8/1/65

Internet

http://www.molecularpain.com/content/8/1/65

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