Rapamycin mitigates inflammation‐mediated disc matrix homeostatic imbalance by inhibiting mTORC1 and inducing autophagy through Akt activation

Rapamycin mitigates inflammation‐mediated disc matrix homeostatic imbalance by inhibiting mTORC1 and inducing autophagy through Akt activation

Abstract Background Low back pain is a global health problem that originated mainly from intervertebral disc degeneration (IDD). Autophagy, negatively regulated by the phosphatidylinositol 3‐kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway, prevents metabolic and degenerative...

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Bibliographic Details
Main Authors: Takashi Yurube, William J. Buchser, Zhongying Zhang, Prashanta Silwal, Michael T. Lotze, James D. Kang, Gwendolyn A. Sowa, Nam V. Vo
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:JOR Spine
Subjects:
autophagy
disc degeneration
inflammation
intervertebral disc
PI3K/Akt/mTOR signaling pathway
rapamycin
Online Access:https://doi.org/10.1002/jsp2.1303

Internet

https://doi.org/10.1002/jsp2.1303

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