Identification and validation of stromal-tumor microenvironment-based subtypes tightly associated with PD-1/PD-L1 immunotherapy and outcomes in patients with gastric cancer

Identification and validation of stromal-tumor microenvironment-based subtypes tightly associated with PD-1/PD-L1 immunotherapy and outcomes in patients with gastric cancer

Abstract Background Immunotherapies targeting programmed cell death 1 (PD-1) and programmed death-ligand 1 (PD-L1) have been approved for gastric cancer (GC) patients. However, a large proportion of patients with T-cell-inflamed tumor microenvironment do not respond to the PD-1/PD-L1 blockade. The s...

Full description

Bibliographic Details
Main Authors: Qianqian Ren, Peng Zhu, Hui Zhang, Tianhe Ye, Dehan Liu, Zhao Gong, Xiangwen Xia
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Cancer Cell International
Subjects:
Gastric cancer
Stromal cells infiltration
Stromal score
Overall survival
PD-1/PD-L1 therapy
Online Access:http://link.springer.com/article/10.1186/s12935-020-01173-3

Internet

http://link.springer.com/article/10.1186/s12935-020-01173-3

Similar Items