Chemometric Analysis of Extracts and Fractions from Green, Oxidized, and Microbial Fermented Teas and Their Correlation to Potential Antioxidant and Anticancer Effects
Previous reports on phytochemicals in green tea (GT) and processed teas mainly focused on more representative compounds such as catechins. Here, we focus on the insignificantly studied non-catechin components in tea extracts, and explore the multivariate correlation between diverse phenolic compound...
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MDPI AG
2020-10-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/9/10/1015 |
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| author | Chan-Su Rha Young Sung Jung Jung-Dae Lee Davin Jang Mi-Seon Kim Min-Seuk Lee Yong Deok Hong Dae-Ok Kim |
| author_facet | Chan-Su Rha Young Sung Jung Jung-Dae Lee Davin Jang Mi-Seon Kim Min-Seuk Lee Yong Deok Hong Dae-Ok Kim |
| author_sort | Chan-Su Rha |
| collection | DOAJ |
| description | Previous reports on phytochemicals in green tea (GT) and processed teas mainly focused on more representative compounds such as catechins. Here, we focus on the insignificantly studied non-catechin components in tea extracts, and explore the multivariate correlation between diverse phenolic compounds in tea and the in vitro antioxidant and anticancer effects. Extracts from GT and four types of processed teas were further divided into hydrophilic and hydrophobic fractions, whose phenolic compositions and antioxidant capacities were quantified using HPLC-MS and three antioxidant assays, respectively. For three types of teas, the anticancer effects of their extracts and fractions were assessed using cancer cell lines. The hydrophobic fractions had lower antioxidant capacities than the corresponding hydrophilic fractions, but exhibited superior antiproliferative effects on cancer cells compared with the whole extract and the hydrophilic fraction. Partial least squares-discriminant analysis revealed a strong correlation between the anticancer effects and the theaflavins and flavonols. Therefore, in addition to catechins, the hydrophobic fraction of tea extracts may have beneficial health effects. |
| first_indexed | 2024-03-10T15:30:50Z |
| format | Article |
| id | doaj.art-b7d01745bc834cdf90dea5ba9f21af47 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T15:30:50Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-b7d01745bc834cdf90dea5ba9f21af472023-11-20T17:40:09ZengMDPI AGAntioxidants2076-39212020-10-01910101510.3390/antiox9101015Chemometric Analysis of Extracts and Fractions from Green, Oxidized, and Microbial Fermented Teas and Their Correlation to Potential Antioxidant and Anticancer EffectsChan-Su Rha0Young Sung Jung1Jung-Dae Lee2Davin Jang3Mi-Seon Kim4Min-Seuk Lee5Yong Deok Hong6Dae-Ok Kim7AMOREPACIFIC R&D Center, Yongin 17074, KoreaDepartment of Food Science and Biotechnology, Kyung Hee University, Yongin 17104, KoreaOsulloc Tea R&D Center, Osulloc Farm Corporation, Seogwipo 63521, KoreaDepartment of Food Science and Biotechnology, Kyung Hee University, Yongin 17104, KoreaDepartment of Food Science and Biotechnology, Kyung Hee University, Yongin 17104, KoreaOsulloc Tea R&D Center, Osulloc Farm Corporation, Seogwipo 63521, KoreaAMOREPACIFIC R&D Center, Yongin 17074, KoreaDepartment of Food Science and Biotechnology, Kyung Hee University, Yongin 17104, KoreaPrevious reports on phytochemicals in green tea (GT) and processed teas mainly focused on more representative compounds such as catechins. Here, we focus on the insignificantly studied non-catechin components in tea extracts, and explore the multivariate correlation between diverse phenolic compounds in tea and the in vitro antioxidant and anticancer effects. Extracts from GT and four types of processed teas were further divided into hydrophilic and hydrophobic fractions, whose phenolic compositions and antioxidant capacities were quantified using HPLC-MS and three antioxidant assays, respectively. For three types of teas, the anticancer effects of their extracts and fractions were assessed using cancer cell lines. The hydrophobic fractions had lower antioxidant capacities than the corresponding hydrophilic fractions, but exhibited superior antiproliferative effects on cancer cells compared with the whole extract and the hydrophilic fraction. Partial least squares-discriminant analysis revealed a strong correlation between the anticancer effects and the theaflavins and flavonols. Therefore, in addition to catechins, the hydrophobic fraction of tea extracts may have beneficial health effects.https://www.mdpi.com/2076-3921/9/10/1015anticancer effectantioxidant capacityhigh-performance liquid chromatography-mass spectrometryfermented green teamultivariate analysisoxidized green tea |
| spellingShingle | Chan-Su Rha Young Sung Jung Jung-Dae Lee Davin Jang Mi-Seon Kim Min-Seuk Lee Yong Deok Hong Dae-Ok Kim Chemometric Analysis of Extracts and Fractions from Green, Oxidized, and Microbial Fermented Teas and Their Correlation to Potential Antioxidant and Anticancer Effects Antioxidants anticancer effect antioxidant capacity high-performance liquid chromatography-mass spectrometry fermented green tea multivariate analysis oxidized green tea |
| title | Chemometric Analysis of Extracts and Fractions from Green, Oxidized, and Microbial Fermented Teas and Their Correlation to Potential Antioxidant and Anticancer Effects |
| title_full | Chemometric Analysis of Extracts and Fractions from Green, Oxidized, and Microbial Fermented Teas and Their Correlation to Potential Antioxidant and Anticancer Effects |
| title_fullStr | Chemometric Analysis of Extracts and Fractions from Green, Oxidized, and Microbial Fermented Teas and Their Correlation to Potential Antioxidant and Anticancer Effects |
| title_full_unstemmed | Chemometric Analysis of Extracts and Fractions from Green, Oxidized, and Microbial Fermented Teas and Their Correlation to Potential Antioxidant and Anticancer Effects |
| title_short | Chemometric Analysis of Extracts and Fractions from Green, Oxidized, and Microbial Fermented Teas and Their Correlation to Potential Antioxidant and Anticancer Effects |
| title_sort | chemometric analysis of extracts and fractions from green oxidized and microbial fermented teas and their correlation to potential antioxidant and anticancer effects |
| topic | anticancer effect antioxidant capacity high-performance liquid chromatography-mass spectrometry fermented green tea multivariate analysis oxidized green tea |
| url | https://www.mdpi.com/2076-3921/9/10/1015 |
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