Triptolide protects against podocyte injury in diabetic nephropathy by activating the Nrf2/HO-1 pathway and inhibiting the NLRP3 inflammasome pathway

Triptolide protects against podocyte injury in diabetic nephropathy by activating the Nrf2/HO-1 pathway and inhibiting the NLRP3 inflammasome pathway

AbstractObjectives Diabetic nephropathy (DN) is the most common microvascular complication of diabetes mellitus. This study investigated the mechanism of triptolide (TP) in podocyte injury in DN.Methods DN mouse models were established by feeding with a high-fat diet and injecting with streptozocin...

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Bibliographic Details
Main Authors: Chenlei Lv, Tianyang Cheng, Bingbing Zhang, Ke Sun, Keda Lu
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Renal Failure
Subjects:
Diabetic nephropathy
MPC5
triptolide
NLRP3 inflammasome
Nrf2
oxidative stress
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2023.2165103

Internet

https://www.tandfonline.com/doi/10.1080/0886022X.2023.2165103

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