Cognate DNA Recognition by Engrailed Homeodomain Involves a Conformational Change Controlled via an Electrostatic-Spring-Loaded Latch

Cognate DNA Recognition by Engrailed Homeodomain Involves a Conformational Change Controlled via an Electrostatic-Spring-Loaded Latch

Transcription factors must scan genomic DNA, recognize the cognate sequence of their control element(s), and bind tightly to them. The DNA recognition process is primarily carried out by their DNA binding domains (DBD), which interact with the cognate site with high affinity and more weakly with any...

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Bibliographic Details
Main Authors: Nicola D’Amelio, Benjamin Tanielian, Mourad Sadqi, Pilar López-Navajas, Victor Muñoz
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
protein–DNA interactions
DNA recognition
transcription factors
DNA binding domains
conformational change
nuclear magnetic resonance
Online Access:https://www.mdpi.com/1422-0067/23/5/2412

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https://www.mdpi.com/1422-0067/23/5/2412

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