Exosomal MiR-4261 mediates calcium overload in RBCs by downregulating the expression of ATP2B4 in multiple myeloma

Exosomal MiR-4261 mediates calcium overload in RBCs by downregulating the expression of ATP2B4 in multiple myeloma

BackgroundHypercalcemia induced by multiple myeloma (MM) affects the biological functions of excitable and non-excitable cells. However, red blood cells (RBCs) regulatory effect on calcium in hypercalcemia is still not fully understood.MethodsA total of 113 patients with MM osteolytic lesions were s...

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Bibliographic Details
Main Authors: Sicheng Bian, Xialin Zhang, Leilei Lin, Lili Sun, Zhibo Guo, Jie Pan, Jiangxia Cui, Hanbing Yao, Jing Xu, Zhuanghui Hao, Yuzhu Wang, Liguo Tong, Xingpeng Bu, Desheng Kong, Nianjiao Liu, Yinghua Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
ATP2B4
calcium overload
RBC
multiple myeloma
miR-4261
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.978755/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.978755/full

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