Genomic Adaption and Mutational Patterns in a HaCaT Subline Resistant to Alkylating Agents and Ionizing Radiation

Genomic Adaption and Mutational Patterns in a HaCaT Subline Resistant to Alkylating Agents and Ionizing Radiation

Sulfur mustard (SM) is a chemical warfare agent that can damage DNA via alkylation and oxidative stress. Because of its genotoxicity, SM is cancerogenic and the progenitor of many chemotherapeutics. Previously, we developed an SM-resistant cell line via chronic exposure of the popular keratinocyte c...

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Bibliographic Details
Main Authors: Reinhard Ullmann, Benjamin Valentin Becker, Simone Rothmiller, Annette Schmidt, Horst Thiermann, Hanns Leonhard Kaatsch, Gerrit Schrock, Jessica Müller, Julia Jakobi, Richard Obermair, Matthias Port, Harry Scherthan
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
chronic exposure
DNA alkylation
genome rearrangements
HaCaT
irradiation
mutational signatures
Online Access:https://www.mdpi.com/1422-0067/22/3/1146

Internet

https://www.mdpi.com/1422-0067/22/3/1146

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