CH vs. HC—Promiscuous Metal Sponges in Antimicrobial Peptides and Metallophores

CH vs. HC—Promiscuous Metal Sponges in Antimicrobial Peptides and Metallophores

Histidine and cysteine residues, with their imidazole and thiol moieties that deprotonate at approximately physiological pH values, are primary binding sites for Zn(II), Ni(II) and Fe(II) ions and are thus ubiquitous both in peptidic metallophores and in antimicrobial peptides that may use nutrition...

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Bibliographic Details
Main Authors: Kinga Garstka, Valentyn Dzyhovskyi, Joanna Wątły, Kamila Stokowa-Sołtys, Jolanta Świątek-Kozłowska, Henryk Kozłowski, Miquel Barceló-Oliver, Denise Bellotti, Magdalena Rowińska-Żyrek
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Molecules
Subjects:
bioinorganic chemistry
antimicrobial peptides
metallophores
thermodynamics
potentiometry
metal coordination
Online Access:https://www.mdpi.com/1420-3049/28/10/3985

Internet

https://www.mdpi.com/1420-3049/28/10/3985

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