Single Amino Acid Substitution N659D in HIV-2 Envelope Glycoprotein (Env) Impairs Viral Release and Hampers BST-2 Antagonism

Single Amino Acid Substitution N659D in HIV-2 Envelope Glycoprotein (Env) Impairs Viral Release and Hampers BST-2 Antagonism

BST-2 or tetherin is a host cell restriction factor that prevents the budding of enveloped viruses at the cell surface, thus impairing the viral spread. Several countermeasures to evade this antiviral factor have been positively selected in retroviruses: the human immunodeficiency virus type 2 (HIV-...

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Bibliographic Details
Main Authors: François E. Dufrasne, Catherine Lombard, Patrick Goubau, Jean Ruelle
Format: Article
Language:English
Published: MDPI AG 2016-10-01
Series:Viruses
Subjects:
HIV-2
BST-2
tetherin
gp36
envelope glycoprotein
Env
restriction factors
viral antagonist
FRET
CRISPR/Cas9 knockout
Online Access:http://www.mdpi.com/1999-4915/8/10/285

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http://www.mdpi.com/1999-4915/8/10/285

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