Subtype-specific expression of MELK is partly due to copy number alterations in breast cancer.

Subtype-specific expression of MELK is partly due to copy number alterations in breast cancer.

Maternal embryonic leucine-zipper kinase (MELK) regulates cell cycle progression and is highly expressed in many cancers. The molecular mechanism of MELK dysregulation has not been determined in aggressive forms of breast cancer, such as triple negative breast cancer (TNBC). To evaluate molecular ma...

Full description

Bibliographic Details
Main Authors:	Ashley A Hardeman, Yoo Jane Han, Tatyana A Grushko, Jeffrey Mueller, Maria J Gomez, Yonglan Zheng, Olufunmilayo I Olopade
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2022-01-01
Series:	PLoS ONE
Online Access:	https://doi.org/10.1371/journal.pone.0268693

Similar Items

Molecular Subtype-Specific Expression of MicroRNA-29c in Breast Cancer Is Associated with CpG Dinucleotide Methylation of the Promoter.
by: Elizabeth Poli, et al.
Published: (2015-01-01)

Identification of Breast Cancer Subtype-Specific Biomarkers by Integrating Copy Number Alterations and Gene Expression Profiles
by: Claudia Cava, et al.
Published: (2021-03-01)

Functional copy-number alterations in cancer.
by: Barry S Taylor, et al.
Published: (2008-09-01)

Signatures of Discriminative Copy Number Aberrations in 31 Cancer Subtypes
by: Bo Gao, et al.
Published: (2021-05-01)

Comparison of Genomic Copy Number Variations Among Breast Cancer Subtypes
by: WANG Zhihui, et al.
Published: (2021-04-01)

“Secundum rubricam romanam”: Reform Liturgy of Subiaco-Melk
by: Robert Klugseder
Published: (2015-06-01)

Prognostic Value of Copy Number Alteration Burden in Early-Stage Breast Cancer and the Construction of an 11-Gene Copy Number Alteration Model
by: Dingyuan Wang, et al.
Published: (2022-08-01)

Genetic and Epigenetic Regulation of TOX3 Expression in Breast Cancer.
by: Yoo-Jeong Han, et al.
Published: (2016-01-01)

Identification and Analysis of Sex-Biased Copy Number Alterations
by: Chenhao Zhang, et al.
Published: (2024-01-01)

DNA rare copy number alterations in Reinke’s Edema
by: Luis Eduardo Silva Móz, et al.
Published: (2023-03-01)

Evolution and vulnerabilities of somatic copy number alterations in cancer
by: Gibson, William J., Ph. D. Massachusetts Institute of Technology
Published: (2016)

Exploratory analysis of the copy number alterations in glioblastoma multiforme.
by: Pablo Freire, et al.
Published: (2008-01-01)

Determining frequent patterns of copy number alterations in cancer.
by: Franck Rapaport, et al.
Published: (2010-08-01)

Copy number alteration of neuropeptides and receptors in multiple cancers
by: Min Zhao, et al.
Published: (2017-07-01)

Histotype-specific copy-number alterations in ovarian cancer
by: Huang Ruby YunJu, et al.
Published: (2012-10-01)

Copy number alterations in cancer: detection and precision medicine
by: Gusnanto Arief
Published: (2021-01-01)

Recurrent chromosomal copy number alterations in sporadic chordomas.
by: Long Phi Le, et al.
Published: (2011-01-01)

PAK1 copy number in breast cancer—Associations with proliferation and molecular subtypes
by: Anette H. Skjervold, et al.
Published: (2023-01-01)

Total copy number variation as a prognostic factor in adult astrocytoma subtypes
by: Kanish Mirchia, et al.
Published: (2019-06-01)

MELK is a prognostic biomarker and correlated with immune infiltration in glioma
by: Haiyan Yang, et al.
Published: (2022-10-01)

MELK is not necessary for the proliferation of basal-like breast cancer cells
by: Hai-Tsang Huang, et al.
Published: (2017-09-01)

MELK—a conserved kinase: functions, signaling, cancer, and controversy
by: Ranjit Ganguly, et al.
Published: (2015-12-01)

Prognostic Values of Gene Copy Number Alterations in Prostate Cancer
by: Abdulaziz Alfahed, et al.
Published: (2023-04-01)

Prevalence and prevention of large-scale somatic copy number alterations
by: Knouse, Kristin Ann
Published: (2017)

Gene Copy-Number Alterations: A Cost-Benefit Analysis
by: Tang, Yun-Chi, et al.
Published: (2016)

Detection of Copy Number Alterations Using Single Cell Sequencing
by: Knouse, Kristin Ann, et al.
Published: (2018)

The landscape of somatic copy-number alteration across human cancers
by: Lander, Eric Steven
Published: (2012)

Estimation of copy number alterations from exome sequencing data.
by: Rafael Valdés-Mas, et al.
Published: (2012-01-01)

Improved Uveal Melanoma Copy Number Subtypes Including an Ultra–High-Risk Group
by: Emilie Lalonde, PhD, et al.
Published: (2022-06-01)

Preclinical assessment of synergistic efficacy of MELK and CDK inhibitors in adrenocortical cancer
by: Dipranjan Laha, et al.
Published: (2022-09-01)

MELK expression correlates with tumor mitotic activity but is not required for cancer growth
by: Christopher J Giuliano, et al.
Published: (2018-02-01)

MELK Promotes Melanoma Growth by Stimulating the NF-κB Pathway
by: Radoslav Janostiak, et al.
Published: (2017-12-01)

Coexisting Molecular Alterations Increase the Risk of Malignancy in Thyroid Nodules with Copy Number Alterations
by: Mohannad Rajab, et al.
Published: (2022-12-01)

Spatially resolved clonal copy number alterations in benign and malignant tissue
by: Erickson, A, et al.
Published: (2022)

Survival-Critical Genes Associated with Copy Number Alterations in Lung Adenocarcinoma
by: Chinthalapally V. Rao, et al.
Published: (2021-05-01)

Copy Number Alterations as Novel Biomarkers and Therapeutic Targets in Colorectal Cancer
by: Elaine S. Tan, et al.
Published: (2022-04-01)

MDM2 Oncogene Copy Number Alterations in Chronic Lymphocytic Leukemia
by: Pathum Sookaromdee, et al.
Published: (2019-08-01)

Identification of Medium-Sized Copy Number Alterations in Whole-Genome Sequencing
by: Hatice Gulcin Ozer, et al.
Published: (2015-03-01)

Comparative analysis of methods for identifying recurrent copy number alterations in cancer.
by: Xiguo Yuan, et al.
Published: (2012-01-01)

Identification of Medium-Sized Copy Number Alterations in Whole-Genome Sequencing
by: Hatice Gulcin Ozer, et al.
Published: (2014-01-01)