The cryo‐EM structure of full‐length RAD52 protein contains an undecameric ring

The cryo‐EM structure of full‐length RAD52 protein contains an undecameric ring

The human RAD52 protein, which forms an oligomeric ring structure, is involved in DNA double‐strand break repair. The N‐terminal half of RAD52 is primarily responsible for self‐oligomerisation and DNA binding. Crystallographic studies have revealed the detailed structure of the N‐terminal half. Howe...

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Bibliographic Details
Main Authors: Chiaki Kinoshita, Yoshimasa Takizawa, Mika Saotome, Shun Ogino, Hitoshi Kurumizaka, Wataru Kagawa
Format: Article
Language:English
Published: Wiley 2023-03-01
Series:FEBS Open Bio
Subjects:
cryo‐electron microscopy
DNA annealing protein
DNA double‐strand break repair
intrinsically disordered region
oligomerisation
ring structure
Online Access:https://doi.org/10.1002/2211-5463.13565

Internet

https://doi.org/10.1002/2211-5463.13565

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