Drug-Targeted Genomes: Mutability of Ion Channels and GPCRs

Drug-Targeted Genomes: Mutability of Ion Channels and GPCRs

Mutations of ion channels and G-protein-coupled receptors (GPCRs) are not uncommon and can lead to cardiovascular diseases. Given previously reported multiple factors associated with high mutation rates, we sorted the relative mutability of multiple human genes by (i) proximity to telomeres and/or (...

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Bibliographic Details
Main Authors: Regan Raines, Ian McKnight, Hunter White, Kaitlyn Legg, Chan Lee, Wei Li, Peter H. U. Lee, Joon W. Shim
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Biomedicines
Subjects:
target therapy
ion channels
GPCRs
telomere
mutation
cardiovascular pharmacology
Online Access:https://www.mdpi.com/2227-9059/10/3/594

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https://www.mdpi.com/2227-9059/10/3/594

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