Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability

Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability

Abstract Background Cytosine DNA methylation is widely described as a transcriptional repressive mark with the capacity to silence promoters. Epigenome engineering techniques enable direct testing of the effect of induced DNA methylation on endogenous promoters; however, the downstream effects have...

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Bibliographic Details
Main Authors: Alex de Mendoza, Trung Viet Nguyen, Ethan Ford, Daniel Poppe, Sam Buckberry, Jahnvi Pflueger, Matthew R. Grimmer, Sabine Stolzenburg, Ozren Bogdanovic, Alicia Oshlack, Peggy J. Farnham, Pilar Blancafort, Ryan Lister
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Genome Biology
Subjects:
DNA methylation
Epigenome engineering
CpG islands
DNMT
Zinc finger
Promoter regulation
Online Access:https://doi.org/10.1186/s13059-022-02728-5

Internet

https://doi.org/10.1186/s13059-022-02728-5

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