Stable-Isotope Dilution GC–MS Measurement of Metformin in Human Serum and Urine after Derivatization with Pentafluoropropionic Anhydride and Its Application in Becker Muscular Dystrophy Patients Administered with Metformin, <span style="font-variant: small-caps">l</span>-Citrulline, or Their Combination

Stable-Isotope Dilution GC–MS Measurement of Metformin in Human Serum and Urine after Derivatization with Pentafluoropropionic Anhydride and Its Application in Becker Muscular Dystrophy Patients Administered with Metformin, <span style="font-variant: small-caps">l</span>-Citrulline, or Their Combination

Metformin (<i>N</i>,<i>N</i>-dimethylguanylguanidine) is one of the most prescribed drugs with pleiotropic, exerted in part by not fully elucidated mechanisms of action. We developed and validated a gas chromatography–mass spectrometry (GC–MS) method for the quantitative anal...

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Bibliographic Details
Main Authors: Svetlana Baskal, Alexander Bollenbach, Bettina Henzi, Patricia Hafner, Dirk Fischer, Dimitrios Tsikas
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
derivatization
metformin
GC–MS
pentafluoropropionic anhydride
serum
stability
Online Access:https://www.mdpi.com/1420-3049/27/12/3850

Internet

https://www.mdpi.com/1420-3049/27/12/3850

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