Montelukast Disposition: No Indication of Transporter-Mediated Uptake in OATP2B1 and OATP1B1 Expressing HEK293 Cells

Montelukast Disposition: No Indication of Transporter-Mediated Uptake in OATP2B1 and OATP1B1 Expressing HEK293 Cells

Clinical studies with montelukast show variability in effect and polymorphic OATP2B1-dependent absorption has previously been implicated as a possible cause. This claim has been challenged with conflicting data and here we used OATP2B1-transfected HEK293 cells to clarify the mechanisms involved. For...

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Bibliographic Details
Main Authors: Marie Brännström, Pär Nordell, Britta Bonn, Andrew M. Davis, Anna-Pia Palmgren, Constanze Hilgendorf, Katarina Rubin, Ken Grime
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Pharmaceutics
Subjects:
montelukast
OATP2B1
OATP1B1
hepatic uptake
transporters
Online Access:http://www.mdpi.com/1999-4923/7/4/554

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http://www.mdpi.com/1999-4923/7/4/554

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