Proof-of-concept for effective antiviral activity of an in silico designed decoy synthetic mRNA against SARS-CoV-2 in the Vero E6 cell-based infection model

Proof-of-concept for effective antiviral activity of an in silico designed decoy synthetic mRNA against SARS-CoV-2 in the Vero E6 cell-based infection model

The positive-sense single-stranded (ss) RNA viruses of the Betacoronavirus (beta-CoV) genus can spillover from mammals to humans and are an ongoing threat to global health and commerce, as demonstrated by the current zoonotic pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)....

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Bibliographic Details
Main Authors: Nofar Atari, Oran Erster, Yair Heskiau Shteinberg, Hadar Asraf, Eitan Giat, Michal Mandelboim, Itamar Goldstein
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Microbiology
Subjects:
SARS-CoV-2
antivirals
mRNA
Betacoronavirus
in silico
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1113697/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2023.1113697/full

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