Specific Interaction of DARPin with HIV-1 CA<sub>NTD</sub> Disturbs the Distribution of Gag, RNA Packaging, and Tetraspanin Remodelling in the Membrane

Specific Interaction of DARPin with HIV-1 CA<sub>NTD</sub> Disturbs the Distribution of Gag, RNA Packaging, and Tetraspanin Remodelling in the Membrane

A designed repeat scaffold protein (Ank<sup>GAG</sup>1D4) recognizing the human immunodeficiency virus-1 (HIV-1) capsid (CA) was formerly established with antiviral assembly. Here, we investigated the molecular mechanism of Ank<sup>GAG</sup>1D4 function during the late stages...

Full description

Bibliographic Details
Main Authors: Sutpirat Moonmuang, Rawiwan Maniratanachote, Paninee Chetprayoon, Kanokporn Sornsuwan, Weeraya Thongkum, Koollawat Chupradit, Chatchai Tayapiwatana
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Viruses
Subjects:
HIV-1
Gag polyprotein
virus assembly inhibitor
ankyrin
tetraspanin
Online Access:https://www.mdpi.com/1999-4915/14/4/824

Internet

https://www.mdpi.com/1999-4915/14/4/824

Similar Items