Effect of fosmidomycin on metabolic and transcript profiles of the methylerythritol phosphate pathway in Plasmodium falciparum
In Plasmodium falciparum, the formation of isopentenyl diphosphate and dimethylallyl diphosphate, central intermediates in the biosynthesis of isoprenoids, occurs via the methylerythritol phosphate (MEP) pathway. Fosmidomycin is a specific inhibitor of the second enzyme of the MEP pathway, 1-deoxy-D...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
2007-06-01
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Series: | Memorias do Instituto Oswaldo Cruz |
Subjects: | |
Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000300019 |