Effect of fosmidomycin on metabolic and transcript profiles of the methylerythritol phosphate pathway in Plasmodium falciparum

Effect of fosmidomycin on metabolic and transcript profiles of the methylerythritol phosphate pathway in Plasmodium falciparum

In Plasmodium falciparum, the formation of isopentenyl diphosphate and dimethylallyl diphosphate, central intermediates in the biosynthesis of isoprenoids, occurs via the methylerythritol phosphate (MEP) pathway. Fosmidomycin is a specific inhibitor of the second enzyme of the MEP pathway, 1-deoxy-D...

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Bibliographic Details
Main Authors:	María B Cassera, Emilio F Merino, Valnice J Peres, Emilia A Kimura, Gerhard Wunderlich, Alejandro M Katzin
Format:	Article
Language:	English
Published:	Fundação Oswaldo Cruz (FIOCRUZ) 2007-06-01
Series:	Memorias do Instituto Oswaldo Cruz
Subjects:	Plasmodium falciparum malaria fosmidomycin isoprenoid biosynthesis real time polymerase chain reaction
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762007000300019

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