Targeting immunosuppressive Ly6C+ classical monocytes reverses anti-PD-1/CTLA-4 immunotherapy resistance

Targeting immunosuppressive Ly6C+ classical monocytes reverses anti-PD-1/CTLA-4 immunotherapy resistance

IntroductionDespite significant clinical advancement with the use of immune checkpoint blockade (ICB) in non-small cell lung cancer (NSCLC) there are still a major subset of patients that develop adaptive/acquired resistance. Understanding resistance mechanisms to ICB is critical to developing new t...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: B. Leticia Rodriguez, Limo Chen, Yanli Li, Shucheng Miao, David H. Peng, Jared J. Fradette, Lixia Diao, Jessica M. Konen, Frank R. Rojas Alvarez, Luisa M. Solis, Xiaohui Yi, Aparna Padhye, Laura A. Gibson, Joshua K. Ochieng, Xiaofei Zhou, Jing Wang, Don L. Gibbons
Format: Artykuł
Język:English
Wydane: Frontiers Media S.A. 2023-06-01
Seria:Frontiers in Immunology
Hasła przedmiotowe:
monocytes
immunotherapy
resistance
myeloid cells
PD-1/CTLA-4 immunotherapy
Dostęp online:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1161869/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1161869/full

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