Correlative proteomics identify the key roles of stress tolerance strategies in Acinetobacter baumannii in response to polymyxin and human macrophages.
The opportunistic pathogen Acinetobacter baumannii possesses stress tolerance strategies against host innate immunity and antibiotic killing. However, how the host-pathogen-antibiotic interaction affects the overall molecular regulation of bacterial pathogenesis and host response remains unexplored....
Main Authors: | Zhi Ying Kho, Mohammad A K Azad, Mei-Ling Han, Yan Zhu, Cheng Huang, Ralf B Schittenhelm, Thomas Naderer, Tony Velkov, Joel Selkrig, Qi Tony Zhou, Jian Li |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2022-03-01
|
Series: | PLoS Pathogens |
Online Access: | https://doi.org/10.1371/journal.ppat.1010308 |
Similar Items
-
30: SPOT-MEDIATED UNIQUE METABOLIC REMODELLING POTENTIALLY UNDERLIES THE POLYMYXIN TOLERANCE IN ACINETOBACTER BAUMANNII
by: Z.Y. Kho, et al.
Published: (2022-11-01) -
Synergistic Killing of Polymyxin B in Combination With the Antineoplastic Drug Mitotane Against Polymyxin-Susceptible and -Resistant Acinetobacter baumannii: A Metabolomic Study
by: Thien B. Tran, et al.
Published: (2018-04-01) -
Arginine catabolism is essential to polymyxin dependence in Acinetobacter baumannii
by: Mei-Ling Han, et al.
Published: (2024-07-01) -
Metabolic Responses to Polymyxin Treatment in Acinetobacter baumannii ATCC 19606: Integrating Transcriptomics and Metabolomics with Genome-Scale Metabolic Modeling
by: Yan Zhu, et al.
Published: (2019-02-01) -
Mechanisms Underlying Synergistic Killing of Polymyxin B in Combination with Cannabidiol against <i>Acinetobacter baumannii</i>: A Metabolomic Study
by: Maytham Hussein, et al.
Published: (2022-04-01)