The Product of Matrix Metalloproteinase Cleavage of Doxorubicin Conjugate for Anticancer Drug Delivery: Calorimetric, Spectroscopic, and Molecular Dynamics Studies on Peptide–Doxorubicin Binding to DNA

The Product of Matrix Metalloproteinase Cleavage of Doxorubicin Conjugate for Anticancer Drug Delivery: Calorimetric, Spectroscopic, and Molecular Dynamics Studies on Peptide–Doxorubicin Binding to DNA

Matrix metalloproteinases (MMPs) are extracellular matrix degradation factors, promoting cancer progression. Hence, they could provide an enzyme-assisted delivery of doxorubicin (DOX) in cancer treatment. In the current study, the intercalation process of DOX and tetrapeptide–DOX, the product of the...

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Bibliographic Details
Main Authors: Kamila Butowska, Krzysztof Żamojć, Mateusz Kogut, Witold Kozak, Dariusz Wyrzykowski, Wiesław Wiczk, Jacek Czub, Jacek Piosik, Janusz Rak
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
doxorubicin
matrix metalloproteinases
intercalation
DNA
cleavable peptide
drug delivery
Online Access:https://www.mdpi.com/1422-0067/21/18/6923

Internet

https://www.mdpi.com/1422-0067/21/18/6923

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