Lyophilization of Liposomal Formulations: Still Necessary, Still Challenging

Lyophilization of Liposomal Formulations: Still Necessary, Still Challenging

Nowadays, the freeze-drying of liposome dispersions is still necessary to provide a solid dosage form intended for different routes of administration (i.e., parenteral, oral, nasal and/or pulmonary). However, after decades of studies the optimization of process conditions remains still challenging s...

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Bibliographic Details
Main Authors: Silvia Franzé, Francesca Selmin, Elena Samaritani, Paola Minghetti, Francesco Cilurzo
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Pharmaceutics
Subjects:
cake appearance
cryoprotectant
freeze-drying
freezing rate
time and temperature
liposomes
lyoprotectant
QbD
solvent
stability
sublimation
Online Access:http://www.mdpi.com/1999-4923/10/3/139

Internet

http://www.mdpi.com/1999-4923/10/3/139

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