TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats

TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats

Abstract Background Nucleotide-binding oligomerization domain-like receptor pyrin domain-containing protein 3 (NLRP3) plays an important role in mediating inflammatory responses during ischemic stroke. Bile acid receptor Takeda-G-protein-receptor-5 (TGR5) has been identified as an important componen...

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Bibliographic Details
Main Authors: Hui Liang, Nathanael Matei, Devin W. McBride, Yang Xu, Zhenhua Zhou, Jiping Tang, Benyan Luo, John H. Zhang
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Journal of Neuroinflammation
Subjects:
TGR5
Inflammation
Neuroprotection
Middle cerebral artery occlusion
Early brain injury
Online Access:https://doi.org/10.1186/s12974-021-02087-1

Internet

https://doi.org/10.1186/s12974-021-02087-1

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