Majority of human circulating IgG plasmablasts stop blasting in a cell-free pro-survival culture

Majority of human circulating IgG plasmablasts stop blasting in a cell-free pro-survival culture

Abstract Following infection or vaccination, early-minted antibody secreting cells (ASC) or plasmablasts appear in circulation transiently, and a small fraction migrates to the spleen or bone marrow (BM) to mature into long-lived plasma cells (LLPC). While LLPC, by definition, are quiescent or non-d...

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Bibliographic Details
Main Authors: Doan C. Nguyen, Celia Saney, Ian T. Hentenaar, Monica Cabrera-Mora, Violeta Capric, Matthew C. Woodruff, Joel Andrews, Sagar Lonial, Ignacio Sanz, F. Eun-Hyung Lee
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-53977-2

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https://doi.org/10.1038/s41598-024-53977-2

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