Case report: Rapid resolution of grade IV ICANS after first line intrathecal chemotherapy with methotrexate, cytarabine and dexamethasone

Case report: Rapid resolution of grade IV ICANS after first line intrathecal chemotherapy with methotrexate, cytarabine and dexamethasone

Corticosteroid therapy is the mainstay of immune effector cell-associated neurotoxicity syndrome (ICANS) management, although its use has been associated with worse overall survival (OS) and progression-free survival (PFS) after chimeric antigen receptor T-cell (CAR-T cell) therapy. Many options are...

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Bibliographic Details
Main Authors: Mikalai Katsin, Tatsiana Shman, Alexandr Migas, Dzmitry Lutskovich, Yuliya Serada, Yauheniya Khalankova, Yuliya Kostina, Simon Dubovik
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-05-01
Series:Frontiers in Immunology
Subjects:
ICANS
intrathecal chemotherapy
CD19 CAR-T cells
anakinra
corticosteroids
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1380451/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1380451/full

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