Mesenchymal stromal cells ameliorate oxidative stress-induced islet endothelium apoptosis and functional impairment via Wnt4-β-catenin signaling

Mesenchymal stromal cells ameliorate oxidative stress-induced islet endothelium apoptosis and functional impairment via Wnt4-β-catenin signaling

Abstract Background Islet dysfunction and destruction are the common cause for both type 1 and type 2 diabetes mellitus (T2DM). The islets of Langerhans are highly vascularized miniorgans, and preserving the structural integrity and full function of the microvascular endothelium is vital for protect...

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Main Authors: Lingshu Wang, Li Qing, He Liu, Na Liu, Jingting Qiao, Chen Cui, Tianyi He, Ruxing Zhao, Fuqiang Liu, Fei Yan, Chuan Wang, Kai Liang, Xinghong Guo, Ying H. Shen, Xinguo Hou, Li Chen
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Stem Cell Research & Therapy
Subjects:
Islet endothelium
Mesenchymal stromal cell
Wnt
Online Access:http://link.springer.com/article/10.1186/s13287-017-0640-0

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http://link.springer.com/article/10.1186/s13287-017-0640-0

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