Structural basis for kinase inhibition in the tripartite E. coli HipBST toxin–antitoxin system

Structural basis for kinase inhibition in the tripartite E. coli HipBST toxin–antitoxin system

Many bacteria encode multiple toxin–antitoxin (TA) systems targeting separate, but closely related, cellular functions. The toxin of the Escherichia coli hipBA system, HipA, is a kinase that inhibits translation via phosphorylation of glutamyl-tRNA synthetase. Enteropathogenic E. coli O127:H6 encode...

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Bibliographic Details
Main Authors: René L Bærentsen, Stine V Nielsen, Ragnhild B Skjerning, Jeppe Lyngsø, Francesco Bisiak, Jan Skov Pedersen, Kenn Gerdes, Michael A Sørensen, Ditlev E Brodersen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-11-01
Series:eLife
Subjects:
HipBA
Ser/Thr kinase
STK
TrpS
tRNA synthetase
Online Access:https://elifesciences.org/articles/90400

Internet

https://elifesciences.org/articles/90400

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