Identification of new glutamate decarboxylases from Streptomyces for efficient production of γ-aminobutyric acid in engineered Escherichia coli

Identification of new glutamate decarboxylases from Streptomyces for efficient production of γ-aminobutyric acid in engineered Escherichia coli

Abstract Background Gamma (γ)-Aminobutyric acid (GABA) as a bioactive compound is used extensively in functional foods, pharmaceuticals and agro-industry. It can be biosynthesized via decarboxylation of monosodium glutamate (MSG) or L-glutamic acid (L-Glu) by glutamate decarboxylase (GAD; EC4.1.1.15...

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Bibliographic Details
Main Authors: Haina Yuan, Hongbo Wang, Ozkan Fidan, Yong Qin, Gongnian Xiao, Jixun Zhan
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Journal of Biological Engineering
Subjects:
Glutamate decarboxylase
γ-Aminobutyric acid
Streptomyces
Heterologous expression
Whole-cell biotransformation
Online Access:http://link.springer.com/article/10.1186/s13036-019-0154-7

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http://link.springer.com/article/10.1186/s13036-019-0154-7

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