The Genetic Background Is Shaping Cecal Enlargement in the Absence of Intestinal Microbiota

The Genetic Background Is Shaping Cecal Enlargement in the Absence of Intestinal Microbiota

Germ-free (GF) rodents have become a valuable tool for studying the role of intestinal microbes on the host physiology. The major characteristic of GF rodents is an enlarged cecum. The accumulation of mucopolysaccharides, digestion enzymes and water in the intestinal lumen drives this phenotype. Mic...

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Bibliographic Details
Main Authors: Silvia Bolsega, Anna Smoczek, Chen Meng, Karin Kleigrewe, Tim Scheele, Sebastian Meller, Silke Glage, Holger A. Volk, André Bleich, Marijana Basic
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Nutrients
Subjects:
germ-free animal models
genetic background
microbiota-dependent influences on host physiology
cecal enlargement
metabolism
digestive enzymes
Online Access:https://www.mdpi.com/2072-6643/15/3/636

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https://www.mdpi.com/2072-6643/15/3/636

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