SOX4 and SMARCA4 cooperatively regulate PI3k signaling through transcriptional activation of TGFBR2

SOX4 and SMARCA4 cooperatively regulate PI3k signaling through transcriptional activation of TGFBR2

Abstract Dysregulation of PI3K/Akt signaling is a dominant feature in basal-like or triple-negative breast cancers (TNBC). However, the mechanisms regulating this pathway are largely unknown in this subset of aggressive tumors. Here we demonstrate that the transcription factor SOX4 is a key regulato...

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Bibliographic Details
Main Authors: Gaurav A. Mehta, Steven P. Angus, Christen A. Khella, Kevin Tong, Pooja Khanna, Shelley A. H. Dixon, Michael P. Verzi, Gary L. Johnson, Michael L. Gatza
Format: Article
Language:English
Published: Nature Portfolio 2021-04-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-021-00248-2

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https://doi.org/10.1038/s41523-021-00248-2

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