Angiotensin-(1–7) infusion in COVID-19 patients admitted to the ICU: a seamless phase 1–2 randomized clinical trial

Angiotensin-(1–7) infusion in COVID-19 patients admitted to the ICU: a seamless phase 1–2 randomized clinical trial

Abstract Background The coronavirus-related disease (COVID-19) is mainly characterized by a respiratory involvement. The renin-angiotensin system (RAS) has a relevant role in the pathogenesis of COVID-19, as the virus enters host’s cells via the angiotensin-converting enzyme 2 (ACE2). Methods This i...

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Bibliographic Details
Main Authors: Ana Luiza Valle Martins, Filippo Annoni, Filipe Alex da Silva, Lucas Bolais-Ramos, Gisele Capanema de Oliveira, Renata Cunha Ribeiro, Mirella Monique Lana Diniz, Thuanny Granato Fonseca Silva, Beatriz Dias Pinheiro, Natália Abdo Rodrigues, Alana Helen dos Santos Matos, Daisy Motta-Santos, Maria José Campagnole-Santos, Thiago Verano-Braga, Fabio Silvio Taccone, Robson Augusto Souza Santos
Format: Article
Language:English
Published: SpringerOpen 2024-09-01
Series:Annals of Intensive Care
Subjects:
Angiotensin
ARDS
Coronavirus
Renin angiotensin system
RAS
COVID-19
Online Access:https://doi.org/10.1186/s13613-024-01369-0

Internet

https://doi.org/10.1186/s13613-024-01369-0

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