Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations

Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations

Abstract Background In recent years, research has consistently proven the occurrence of genetic overlap across autoimmune diseases, which supports the existence of common pathogenic mechanisms in autoimmunity. The objective of this study was to further investigate this shared genetic component. Meth...

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Main Authors: Ana Márquez, Martin Kerick, Alexandra Zhernakova, Javier Gutierrez-Achury, Wei-Min Chen, Suna Onengut-Gumuscu, Isidoro González-Álvaro, Luis Rodriguez-Rodriguez, Raquel Rios-Fernández, Miguel A. González-Gay, Coeliac Disease Immunochip Consortium, Rheumatoid Arthritis Consortium International for Immunochip (RACI), International Scleroderma Group, Type 1 Diabetes Genetics Consortium, Maureen D. Mayes, Soumya Raychaudhuri, Stephen S. Rich, Cisca Wijmenga, Javier Martín
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Genome Medicine
Subjects:
Celiac disease
Rheumatoid arthritis
Systemic sclerosis
Type 1 diabetes
Cross-disease meta-analysis, Immunochip
Autoimmune disease, functional enrichment analysis
Online Access:http://link.springer.com/article/10.1186/s13073-018-0604-8

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http://link.springer.com/article/10.1186/s13073-018-0604-8

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