PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells

PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells

Summary: Manipulating molecules that impact T cell receptor (TCR) or cytokine signaling, such as the protein tyrosine phosphatase non-receptor type 2 (PTPN2), has significant potential for advancing T cell-based immunotherapies. Nonetheless, it remains unclear how PTPN2 impacts the activation, survi...

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Bibliographic Details
Main Authors: Markus Flosbach, Susanne G. Oberle, Stefanie Scherer, Jana Zecha, Madlaina von Hoesslin, Florian Wiede, Vijaykumar Chennupati, Jolie G. Cullen, Markus List, Josch K. Pauling, Jan Baumbach, Bernhard Kuster, Tony Tiganis, Dietmar Zehn
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Cell Reports
Subjects:
Protein tyrosine phosphatase non‑receptor type 2 (PTPN2)
T cell memory
programmed T cell expansion
adoptive T cell transfer
immunotherapy
effector T cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720309384

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http://www.sciencedirect.com/science/article/pii/S2211124720309384

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