Shared active site architecture between the large subunit of eukaryotic primase and DNA photolyase.

DNA synthesis during replication relies on RNA primers synthesised by the primase, a specialised DNA-dependent RNA polymerase that can initiate nucleic acid synthesis de novo. In archaeal and eukaryotic organisms, the primase is a heterodimeric enzyme resulting from the constitutive association of a...

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Bibliographic Details
Main Authors: Ludovic Sauguet, Sebastian Klinge, Rajika L Perera, Joseph D Maman, Luca Pellegrini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2852410?pdf=render