Shared active site architecture between the large subunit of eukaryotic primase and DNA photolyase.
DNA synthesis during replication relies on RNA primers synthesised by the primase, a specialised DNA-dependent RNA polymerase that can initiate nucleic acid synthesis de novo. In archaeal and eukaryotic organisms, the primase is a heterodimeric enzyme resulting from the constitutive association of a...
Main Authors: | Ludovic Sauguet, Sebastian Klinge, Rajika L Perera, Joseph D Maman, Luca Pellegrini |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-04-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2852410?pdf=render |
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