The STING Ligand and Delivery System Synergistically Enhance the Immunogenicity of an Intranasal Spike SARS-CoV-2 Vaccine Candidate

The STING Ligand and Delivery System Synergistically Enhance the Immunogenicity of an Intranasal Spike SARS-CoV-2 Vaccine Candidate

The respiratory organ serves as a primary target site for SARS-CoV-2. Thus, the vaccine-stimulating immune response of the respiratory tract is significant in controlling SARS-CoV-2 transmission and disease development. In this study, mucoadhesive nanoparticles were used to deliver SARS-CoV-2 spike...

Full description

Bibliographic Details
Main Authors: Tuksin Jearanaiwitayakul, Jitra Limthongkul, Chernkhwan Kaofai, Suttikarn Apichirapokey, Runglawan Chawengkirttikul, Sompong Sapsutthipas, Panya Sunintaboon, Sukathida Ubol
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Biomedicines
Subjects:
intranasal COVID-19 vaccine
SARS-CoV-2 spike glycoprotein
adjuvant nanodelivery
STING agonist
immunogenicity
Online Access:https://www.mdpi.com/2227-9059/10/5/1142

Internet

https://www.mdpi.com/2227-9059/10/5/1142

Similar Items