Genetic and Epigenetic Changes of Components Affecting the WNT Pathway in Colorectal Carcinomas Stratified by Microsatellite Instability

Genetic and Epigenetic Changes of Components Affecting the WNT Pathway in Colorectal Carcinomas Stratified by Microsatellite Instability

An unselected series of 310 colorectal carcinomas, stratified according to microsatellite instability (MSI) and DNA ploidy, was examined for mutations and/or promoter hypermethylation of five components of the WNT signaling cascade [APC, CTNNB1 (encoding Rcatenin), AXIN2, TCF4, and WISP3] and three...

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Bibliographic Details
Main Authors: Lin Thorstensen, Guro E. Lind, Tone Løvig, Chieu B. Diep, Gunn I. Meling, Torleiv O. Rognum, Ragnhild A. Lothe
Format: Article
Language:English
Published: Elsevier 2005-02-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
WNT signaling
colorectal cancer
genomic instability
mutation
hypermethylation
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558605800119

Internet

http://www.sciencedirect.com/science/article/pii/S1476558605800119

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