Ginsenoside Rg3 Mitigates Atherosclerosis Progression in Diabetic apoE–/– Mice by Skewing Macrophages to the M2 Phenotype

Ginsenoside Rg3 Mitigates Atherosclerosis Progression in Diabetic apoE–/– Mice by Skewing Macrophages to the M2 Phenotype

Atherosclerosis (AS) in diabetic patients is often associated with low stability, which might be largely attributed to unfavorable macrophage polarization and increased inflammatory response induced by hyperglycaemia. Ginsenoside Rg3 is one of the main active principles of Panax Ginseng, which has b...

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Bibliographic Details
Main Authors: Mengqi Guo, Jie Xiao, Xi Sheng, Xinyu Zhang, Yuanyuan Tie, Lei Wang, Lang Zhao, Xiaoping Ji
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Pharmacology
Subjects:
Ginsenoside Rg3
PPARγ
M2 macrophages
atherosclerosis
diabetes
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00464/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00464/full

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