Pyrazole-Enriched Cationic Nanoparticles Induced Early- and Late-Stage Apoptosis in Neuroblastoma Cells at Sub-Micromolar Concentrations

Pyrazole-Enriched Cationic Nanoparticles Induced Early- and Late-Stage Apoptosis in Neuroblastoma Cells at Sub-Micromolar Concentrations

Neuroblastoma (NB) is a severe form of tumor occurring mainly in young children and originating from nerve cells found in the abdomen or next to the spine. NB needs more effective and safer treatments, as the chance of survival against the aggressive form of this disease are very small. Moreover, wh...

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Bibliographic Details
Main Authors: Guendalina Zuccari, Alessia Zorzoli, Danilo Marimpietri, Chiara Brullo, Silvana Alfei
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Pharmaceuticals
Subjects:
neuroblastoma
cationic macromolecules
pyrazoles-based cationic nanoparticles
membrane disruptors
dose- and time-dependent cytotoxicity studies
Annexin-V apoptosis detection
Online Access:https://www.mdpi.com/1424-8247/16/3/393

Internet

https://www.mdpi.com/1424-8247/16/3/393

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