Breakthrough infections by SARS-CoV-2 variants boost cross-reactive hybrid immune responses in mRNA-vaccinated Golden Syrian hamsters.

Breakthrough infections by SARS-CoV-2 variants boost cross-reactive hybrid immune responses in mRNA-vaccinated Golden Syrian hamsters.

Hybrid immunity (vaccination + natural infection) to SARS-CoV-2 provides superior protection to re-infection. We performed immune profiling studies during breakthrough infections in mRNA-vaccinated hamsters to evaluate hybrid immunity induction. The mRNA vaccine, BNT162b2, was dosed to induce bindin...

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Bibliographic Details
Main Authors: Juan García-Bernalt Diego, Gagandeep Singh, Sonia Jangra, Kim Handrejk, Manon Laporte, Lauren A Chang, Sara S El Zahed, Lars Pache, Max W Chang, Prajakta Warang, Sadaf Aslam, Ignacio Mena, Brett T Webb, Christopher Benner, Adolfo García-Sastre, Michael Schotsaert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011805&type=printable

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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011805&type=printable

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