Noise-augmented directional clustering of genetic association data identifies distinct mechanisms underlying obesity.

Clustering genetic variants based on their associations with different traits can provide insight into their underlying biological mechanisms. Existing clustering approaches typically group variants based on the similarity of their association estimates for various traits. We present a new procedure...

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Bibliographic Details
Main Authors: Andrew J Grant, Dipender Gill, Paul D W Kirk, Stephen Burgess
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009975