Vegfa promoter gene hypermethylation at HIF1α binding site is an early contributor to CKD progression after renal ischemia

Vegfa promoter gene hypermethylation at HIF1α binding site is an early contributor to CKD progression after renal ischemia

Abstract Chronic hypoxia is a major contributor to Chronic Kidney Disease (CKD) after Acute Kidney Injury (AKI). However, the temporal relation between the acute insult and maladaptive renal response to hypoxia remains unclear. In this study, we analyzed the time-course of renal hemodynamics, oxidat...

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Bibliographic Details
Main Authors: Andrea Sánchez-Navarro, Rosalba Pérez-Villalva, Adrián Rafael Murillo-de-Ozores, Miguel Ángel Martínez-Rojas, Jesús Rafael Rodríguez‐Aguilera, Norma González, María Castañeda-Bueno, Gerardo Gamba, Félix Recillas-Targa, Norma A. Bobadilla
Format: Article
Language:English
Published: Nature Portfolio 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-88000-5

Internet

https://doi.org/10.1038/s41598-021-88000-5

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