Mutacin 1140 Lantibiotic Variants Are Efficacious Against Clostridium difficile Infection

Mutacin 1140 Lantibiotic Variants Are Efficacious Against Clostridium difficile Infection

Lantibiotics offer an untapped pipeline for the development of novel antibiotics to treat serious Gram-positive (+) infections including Clostridium difficile. Mutacin 1140 (MU1140) is a lantibiotic produced by Streptococcus mutans and acts via a novel mechanism of action, which may limit the develo...

Full description

Bibliographic Details
Main Authors: Johan A. Kers, Robert E. Sharp, Anthony W. Defusco, Jae H. Park, Jin Xu, Mark E. Pulse, William J. Weiss, Martin Handfield
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Microbiology
Subjects:
lanthipeptide
antibiotic
bacteriocin
nisin
mutagenesis
structural variant
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00415/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2018.00415/full

Similar Items