Developing 3D Organoid Raft Cultures from Patient-Derived Xenografts as Rapid Models to Screen Efficacy of Experimental Therapeutics

Developing 3D Organoid Raft Cultures from Patient-Derived Xenografts as Rapid Models to Screen Efficacy of Experimental Therapeutics

Reliable preclinical models are needed for screening new cancer drugs. Thus, we developed an improved 3D tumor organoid model termed “organoid raft cultures” (ORCs). Development of ORCs involved culturing tumors ex vivo on collagen beds (boats) with grid supports to maintain their morphological stru...

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Bibliographic Details
Main Authors: Prachi Bajpai, Nilam Sanjib Banerjee, Dianne W. Moore, Hyung-Gyoon Kim, Farrukh Afaq, Carlo M. Contreras, Martin J. Heslin, Vishnu B. Reddy, Shajan Peter, Sooryanarayana Varambally, Sameer Al Diffalha, Upender Manne
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
organoid raft cultures (ORCs)
patient-derived xenografts (PDX)
colon cancer
navitoclax (ABT-263)
3-dimensional (3D) culture model
Online Access:https://www.mdpi.com/1422-0067/23/22/14392

Internet

https://www.mdpi.com/1422-0067/23/22/14392

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