Selective Heart Irradiation Induces Cardiac Overexpression of the Pro-hypertrophic miR-212

Selective Heart Irradiation Induces Cardiac Overexpression of the Pro-hypertrophic miR-212

Background: A deleterious, late-onset side effect of thoracic radiotherapy is the development of radiation-induced heart disease (RIHD). It covers a spectrum of cardiac pathology including also heart failure with preserved ejection fraction (HFpEF) characterized by left ventricular hypertrophy (LVH)...

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Main Authors: Márta Sárközy, Renáta Gáspár, Ágnes Zvara, Laura Kiscsatári, Zoltán Varga, Bence Kővári, Mónika G. Kovács, Gergő Szűcs, Gabriella Fábián, Petra Diószegi, Gábor Cserni, László G. Puskás, Thomas Thum, Zsuzsanna Kahán, Tamás Csont, Sándor Bátkai
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Oncology
Subjects:
thoracic irradiation
left ventricular hypertrophy
heart failure with preserved ejection fraction (HFpEF)
miRNA-212
FOXO3
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00598/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.00598/full

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