Macrophage-derived exosomal microRNA-501-3p promotes progression of pancreatic ductal adenocarcinoma through the TGFBR3-mediated TGF-β signaling pathway

Macrophage-derived exosomal microRNA-501-3p promotes progression of pancreatic ductal adenocarcinoma through the TGFBR3-mediated TGF-β signaling pathway

Abstract Background Exosomes from cancer cells or immune cells, carrying bio-macromolecules or microRNAs (miRNAs), participate in tumor pathogenesis and progression by modulating microenvironment. Our study aims to investigate the role of these microRNA-501-3p (miR-501-3p) containing exosomes derive...

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Bibliographic Details
Main Authors: Zi Yin, Tingting Ma, Bowen Huang, Lehang Lin, Yu Zhou, Jinhai Yan, Yiping Zou, Sheng Chen
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Pancreatic ductal adenocarcinoma
Exosome
M2 macrophage
MicroRNA-501-3p
TGFBR3
TGF-β signaling pathway
Online Access:http://link.springer.com/article/10.1186/s13046-019-1313-x

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http://link.springer.com/article/10.1186/s13046-019-1313-x

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