An optimized Nurr1 agonist provides disease-modifying effects in Parkinson’s disease models

An optimized Nurr1 agonist provides disease-modifying effects in Parkinson’s disease models

Abstract The nuclear receptor, Nurr1, is critical for both the development and maintenance of midbrain dopamine neurons, representing a promising molecular target for Parkinson’s disease (PD). We previously identified three Nurr1 agonists (amodiaquine, chloroquine and glafenine) that share an identi...

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Bibliographic Details
Main Authors: Woori Kim, Mohit Tripathi, Chunhyung Kim, Satyapavan Vardhineni, Young Cha, Shamseer Kulangara Kandi, Melissa Feitosa, Rohit Kholiya, Eric Sah, Anuj Thakur, Yehan Kim, Sanghyeok Ko, Kaiya Bhatia, Sunny Manohar, Young-Bin Kong, Gagandeep Sindhu, Yoon-Seong Kim, Bruce Cohen, Diwan S. Rawat, Kwang-Soo Kim
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-39970-9

Internet

https://doi.org/10.1038/s41467-023-39970-9

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