Sex and prior exposure jointly shape innate immune responses to a live herpesvirus vaccine

Sex and prior exposure jointly shape innate immune responses to a live herpesvirus vaccine

Background: Both sex and prior exposure to pathogens are known to influence responses to immune challenges, but their combined effects are not well established in humans, particularly in early innate responses critical for shaping subsequent outcomes. Methods: We employed systems immunology approach...

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Bibliographic Details
Main Authors: Foo Cheung, Richard Apps, Lesia Dropulic, Yuri Kotliarov, Jinguo Chen, Tristan Jordan, Marc Langweiler, Julian Candia, Angelique Biancotto, Kyu Lee Han, Nicholas Rachmaninoff, Harlan Pietz, Kening Wang, John S Tsang, Jeffrey I Cohen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-01-01
Series:eLife
Subjects:
herpes simplex
vaccine
systems immunology
innate immunity
transcriptomics
sex dimorphism
Online Access:https://elifesciences.org/articles/80652

Internet

https://elifesciences.org/articles/80652

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